Alternating Electric Fields Therapy in Oncology: A Practical by Eric T. Wong

By Eric T. Wong

This concise textual content presents an entire evaluation of alternating electrical fields remedy -- sometimes called tumor treating fields -- for glioblastoma and different forms of good tumor malignancies. Readers are given a basic realizing of this novel anti-cancer therapy modality via studying from scientific trial info in addition to the actual and phone biology results on tumor cells whilst alternating electrical fields are utilized either in vitro and in vivo.

Chapters illustrate the physics in the back of electrical box propagation in house and different media. this can be by means of a overview of our present realizing of the electrical box results on dividing cells - together with the disruption of cytokinesis, right chromosome segregation and activation at the mobilephone floor chaperons that result in immunogenic cellphone loss of life. info from part III trials for the remedy of recurrent and newly clinically determined glioblastomas are incorporated, in addition to the various ancillary post hoc analyses that have been played via a variety of investigators. the rest of the bankruptcy covers different reliable tumor malignancies, together with non-small mobile lung melanoma, pancreatic melanoma and ovarian melanoma, as this therapy modality is being utilized to systemic malignancies.

Alternating electrical Fields remedy in Oncology bargains oncologists, neurologists, radiation oncologists, biomedical engineers, mobilephone biologists and mitosis researchers the basics wanted for medical practice.

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Extra resources for Alternating Electric Fields Therapy in Oncology: A Practical Guide to Clinical Applications of Tumor Treating Fields

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2003;22(6):33–42. 45. Giladi M, Schneiderman RS, Porat Y, Munster M, Itzhaki A, Mordechovich D, et al. Mitotic disruption and reduced clonogenicity of pancreatic cancer cells in vitro and in vivo by tumor treating fields. Pancreatology. 2014;14(1):54–63.  Wong, and Erno Sajo Tumor Treating Fields (TTFields) use frequency-tuned alternating electric fields at 200 kHz that disrupt tumor cells as they undergo mitosis. The targets of these fields are proteins such as α/β tubulin and septin that have high dipole moments.

23. Kotnik T, Miklavčič D. Theoretical evaluation of voltage inducement on internal membranes of biological cells exposed to electric fields. Biophys J. 2006;90(2):480–91. 24. Pavlin M, Miklavčič D. The effective conductivity and the induced transmembrane potential in dense cell system exposed to DC and AC electric fields. IEEE Trans Plasma Sci. 2009;37(1):99–106. 25. Gowrishankar TR, Weaver JC. An approach to electrical modeling of single and multiple cells. Proc Natl Acad Sci U S A. 2003;100(6):3203–8.

Because the definition of the RMS value for a sine wave is the amplitude divided by 2 , the four time points for the RMS value can be derived by specifying Eq. 6 with a peak voltage of 50 V to solve for t: 50 2 (V ) = 50 (V ) × sin ( 2 × p × f ( Hz ) × t ( s ) + 0 ) t RMS Step 1. æ 1 ö sin -1 ç ÷ è 2ø = 2p f Step 2. æ 1 ö sin -1 ç ÷ è 2 ø yields exactly 1 , indicating that the RMS value of the electric The term 2p 8 potential occurs at every a n for an = 2 n - 1 with n = 1, 2, 3, 4 per cycle. By inspec8f tion, the peak electric potential is irrelevant when solving for tRMS simply because it was cancelled out before reaching step 2.

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